Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae
Published: November 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.5198
Biswajit Biswas, Monojit Mondal, Rajoo Thapa, Debkrishna Mallick, Asok Kumar Datta
1. Assistant Professor, Departments of Pediatrics , Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
2. Resident, Departments of Pediatrics, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
3. Resident, Department of Pediatrics, Golisano Children’s Hospital, Upstate Medical University, 750, E. Adams Street, Syracuse, New York 13210, USA.
4. Resident, Department of Pediatrics, St.Mary’s Hospital, PO30 5TG Newport, Wales, UK.
5. Professor and Head of the Deptartment, Departments of Pediatrics, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
Correspondence
Dr. Biswajit Biswas,
Assistant Professor, Departments of Pediatrics , Burdwan Medical College and Hospital,
Burdwan-713104, West Bengal, India.
Phone : +91-9874179931, E-mail : drbiswasb_cs@yahoo.com.
Klebsiella pneumoniae (K. pneumoniae) causing brain abscess in newborn infants is rare. Presented herein, is a 27-day-old male neonate who developed two frontal lobe abscesses in association with K. pneumoniae sepsis and meningitis. Antibiotic susceptibility testing utilizing the double-disk synergy method (Cefotaxime and Amoxycillin-Clavulanate) confirmed the extended spectrum beta-lactamase (ESBL) production by the isolate. He was treated simultaneously with antibiotics (Meropenem and Amikacin) and abscess aspiration through the anterior fontanelle, with less than satisfactory outcome. ESBL producing K. pneumoniae brain abscess in neonates is extremely rare in the English literature. Emperical carbapenems and aminoglycoside coverage in neonates with K. pneumoniae sepsis and brain abscess, especially in areas with high rate of ESBL producing bacteria may be warranted
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